HMGB3 Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling. Belongs to the HMGB family. Expressed predominantly in placenta. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: Xq28
Cellular Component: 
Molecular Function:  DNA binding, bending; double-stranded DNA binding; four-way junction DNA binding; protein binding
Biological Process:  DNA geometric change; DNA recombination; innate immune response; multicellular organism development; negative regulation of B cell differentiation; negative regulation of myeloid cell differentiation
Disease: Microphthalmia, Syndromic 13
Reference #:  O15347 (UniProtKB)
Alt. Names/Synonyms: high mobility group box 3; High mobility group protein 2a; High mobility group protein 4; High mobility group protein B3; high-mobility group (nonhistone chromosomal) protein 4; high-mobility group box 3; HMG-2a; HMG-4; HMG2A; HMG4; HMGB3; MGC90319; non-histone chromosomal protein
Gene Symbols: HMGB3
Molecular weight: 22,980 Da
Basal Isoelectric point: 8.48  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene