GSTO1 Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family. Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.20.4.2; EC 1.8.5.1; EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 19|19 D1
Cellular Component:  axon; basement membrane; cell body; cytoplasm; cytosol; myelin sheath; nuclear membrane
Molecular Function:  glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; methylarsonate reductase activity; oxidoreductase activity; transferase activity
Biological Process:  cellular response to arsenic-containing substance; L-ascorbic acid biosynthetic process; L-ascorbic acid metabolic process; negative regulation of ryanodine-sensitive calcium-release channel activity; oxidation-reduction process; positive regulation of ryanodine-sensitive calcium-release channel activity; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; xenobiotic catabolic process
Reference #:  O09131 (UniProtKB)
Alt. Names/Synonyms: AA407097; AI194287; AU018802; glutathione S-transferase like; glutathione S-transferase omega 1; Glutathione S-transferase omega-1; Glutathione transferase omega 1 (GSTO 1-1) (p28); glutathione-S-transferase like; GSTO-1; Gsto1; Gstx; Gtsttl; p28
Gene Symbols: Gsto1
Molecular weight: 27,498 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
Select Structure to View Below

GSTO1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene