GLUD1 Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 1.4.1.3; Energy Metabolism - nitrogen; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Oxidoreductase
Chromosomal Location of Human Ortholog: 14 B|14 20.8 cM
Cellular Component:  cytoplasm; mitochondrial matrix; mitochondrion
Molecular Function:  ADP binding; ATP binding; enzyme binding; glutamate dehydrogenase (NAD+) activity; glutamate dehydrogenase [NAD(P)+] activity; GTP binding; leucine binding; NAD+ binding; nucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; protein binding
Biological Process:  cellular amino acid metabolic process; glutamate biosynthetic process; glutamate catabolic process; glutamine metabolic process; oxidation-reduction process; positive regulation of insulin secretion; response to aluminum ion; tricarboxylic acid metabolic process
Reference #:  P26443 (UniProtKB)
Alt. Names/Synonyms: AI118167; DHE3; GDH 1; Gdh-X; Glud; Glud1; Gludl; glutamate dehydrogenase 1; Glutamate dehydrogenase 1, mitochondrial
Gene Symbols: Glud1
Molecular weight: 61,337 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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GLUD1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene