CtIP Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations. Belongs to the COM1/SAE2/CtIP family. Expressed in ER-positive breast cancer lines, but tends to be down-regulated ER-negative cells (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.-.-; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component:  intracellular membrane-bounded organelle; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function:  damaged DNA binding; identical protein binding; protein binding; RNA polymerase II repressing transcription factor binding; single-stranded DNA endodeoxyribonuclease activity; transcription corepressor activity
Biological Process:  blastocyst hatching; cell division; DNA double-strand break processing; DNA double-strand break processing involved in repair via single-strand annealing; DNA repair; DNA replication; double-strand break repair via homologous recombination; G1/S transition of mitotic cell cycle; meiotic cell cycle; negative regulation of G0 to G1 transition; negative regulation of nucleic acid-templated transcription; nucleic acid phosphodiester bond hydrolysis; nucleotide-excision repair; regulation of signal transduction by p53 class mediator; regulation of transcription by RNA polymerase II; response to estradiol
Disease: Jawad Syndrome; Seckel Syndrome 2
Reference #:  Q99708 (UniProtKB)
Alt. Names/Synonyms: CtBP-interacting protein; CTIP; DNA endonuclease RBBP8; RBBP-8; RBBP8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; retinoblastoma-interacting myosin-like; Retinoblastoma-interacting protein and myosin-like; RIM
Gene Symbols: RBBP8
Molecular weight: 101,942 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein