CtIP a transcription factor containing C2H2 zinc fingers. May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein. Abundantly expressed in brain and the immune system and associated with immune system malignancies. Ionizing radiation induces its hyperphosphorylation and dissociation from BRCA1 in an ATM-dependent manner. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.-.-; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component:  intracellular membrane-bounded organelle; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function:  damaged DNA binding; identical protein binding; protein binding; RNA polymerase II repressing transcription factor binding; single-stranded DNA endodeoxyribonuclease activity; transcription corepressor activity
Biological Process:  blastocyst hatching; cell division; DNA double-strand break processing; DNA double-strand break processing involved in repair via single-strand annealing; DNA repair; DNA replication; double-strand break repair via homologous recombination; G1/S transition of mitotic cell cycle; meiotic cell cycle; negative regulation of G0 to G1 transition; negative regulation of nucleic acid-templated transcription; nucleic acid phosphodiester bond hydrolysis; nucleotide-excision repair; regulation of signal transduction by p53 class mediator; regulation of transcription by RNA polymerase II; response to estradiol
Disease: Jawad Syndrome; Seckel Syndrome 2
Reference #:  Q99708 (UniProtKB)
Alt. Names/Synonyms: CtBP-interacting protein; CTIP; DNA endonuclease RBBP8; RBBP-8; RBBP8; retinoblastoma binding protein 8; Retinoblastoma-binding protein 8; retinoblastoma-interacting myosin-like; Retinoblastoma-interacting protein and myosin-like; RIM
Gene Symbols: RBBP8
Molecular weight: 101,942 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CtIP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein