GLUD1 Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC; Energy Metabolism - nitrogen; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Oxidoreductase
Chromosomal Location of human Ortholog: 10q23.2
Cellular Component:  cytoplasm; endoplasmic reticulum; mitochondrial matrix; mitochondrion
Molecular Function:  ADP binding; ATP binding; glutamate dehydrogenase (NAD+) activity; glutamate dehydrogenase (NADP+) activity; glutamate dehydrogenase [NAD(P)+] activity; GTP binding; leucine binding; NAD+ binding; protein binding; protein homodimerization activity
Biological Process:  glutamate biosynthetic process; glutamate catabolic process; glutamine metabolic process; positive regulation of insulin secretion; tricarboxylic acid metabolic process
Disease: Hyperinsulinemic Hypoglycemia, Familial, 6
Reference #:  P00367 (UniProtKB)
Alt. Names/Synonyms: DHE3; epididymis secretory sperm binding protein; epididymis tissue sperm binding protein Li 18mP; GDH; GDH 1; GDH1; GLUD; GLUD1; glutamate dehydrogenase (NAD(P)+); glutamate dehydrogenase 1; Glutamate dehydrogenase 1, mitochondrial; MGC132003
Gene Symbols: GLUD1
Molecular weight: 61,398 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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