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GLUD1
Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 1.4.1.3; Energy Metabolism - nitrogen; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Oxidoreductase |
| Chromosomal Location of human Ortholog: 10q23.2 |
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Cellular Component:
cytoplasm; endoplasmic reticulum; mitochondrial matrix; mitochondrion
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Molecular Function:
ADP binding; ATP binding; glutamate dehydrogenase (NAD+) activity; glutamate dehydrogenase (NADP+) activity; glutamate dehydrogenase [NAD(P)+] activity; GTP binding; leucine binding; NAD+ binding; protein binding; protein homodimerization activity
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Biological Process:
glutamate biosynthetic process; glutamate catabolic process; glutamine metabolic process; positive regulation of insulin secretion; tricarboxylic acid metabolic process
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Disease: Hyperinsulinemic Hypoglycemia, Familial, 6
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Reference #:
P00367
(UniProtKB)
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Alt. Names/Synonyms: DHE3; epididymis secretory sperm binding protein; epididymis tissue sperm binding protein Li 18mP; GDH; GDH 1; GDH1; GLUD; GLUD1; glutamate dehydrogenase (NAD(P)+); glutamate dehydrogenase 1; Glutamate dehydrogenase 1, mitochondrial; MGC132003
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Gene Symbols: GLUD1
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Molecular weight:
61,398 Da
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Basal Isoelectric point:
7.66
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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