SMC2L1 Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Belongs to the SMC family. SMC2 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of mouse Ortholog: 4 B2|4 28.31 cM
Cellular Component:  chromosome; condensed chromosome; condensin complex; cytoplasm; nuclear chromosome; nucleolus; nucleus
Molecular Function:  ATP binding; nucleotide binding; protein binding; protein heterodimerization activity; single-stranded DNA binding
Biological Process:  cell cycle; cell division; chromosome condensation; chromosome organization; kinetochore organization; meiotic chromosome condensation; meiotic chromosome segregation; mitotic chromosome condensation; single strand break repair
Reference #:  Q8CG48 (UniProtKB)
Alt. Names/Synonyms: 5730502P04Rik; AI255214; AW545314; CAP; CAP-E; Cape; Chromosome-associated protein E; FGF-inducible protein 16; fibroblast growth factor inducible 16; Fin; Fin16; OTTMUSP00000007454; SMC protein 2; SMC-2; Smc2; SMC2 structural maintenance of chromosomes 2-like 1; Smc2l1; structural maintenance of chromosomes 2; Structural maintenance of chromosomes protein 2; XCAP-E homolog
Gene Symbols: Smc2
Molecular weight: 134,239 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SMC2L1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene