FBL S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus. Belongs to the methyltransferase superfamily. Fibrillarin family. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.-; Methyltransferase; Nucleolus; RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component:  box C/D snoRNP complex; Cajal body; chromosome; dense fibrillar component; fibrillar center; granular component; nucleolus; nucleoplasm; nucleus
Molecular Function:  ATPase binding; histone-glutamine methyltransferase activity; protein binding; TFIID-class transcription factor complex binding
Biological Process:  histone glutamine methylation; rRNA processing; snoRNA localization
Reference #:  P22087 (UniProtKB)
Alt. Names/Synonyms: 34 kDa nucleolar scleroderma antigen; 34-kD nucleolar scleroderma antigen; FBL; FBRL; FIB; FIB1; fibrillarin; FLRN; Histone-glutamine methyltransferase; Nop1; RNA, U3 small nucleolar interacting protein 1; RNU3IP1; rRNA 2'-O-methyltransferase fibrillarin; U6 snRNA 2'-O-methyltransferase fibrillarin
Gene Symbols: FBL
Molecular weight: 33,784 Da
Basal Isoelectric point: 10.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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