DFFA Inhibitor of the caspase-activated DNase (DFF40). Heterodimer of DFFA and DFFB. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hydrolase
Chromosomal Location of Human Ortholog: 4|4 E2
Cellular Component:  cytoplasm; cytosol; lipid droplet; nuclear chromatin; nucleus; plasma membrane
Molecular Function:  deoxyribonuclease inhibitor activity; protein binding; protein binding involved in protein folding; protein domain specific binding
Biological Process:  apoptotic DNA fragmentation; apoptotic process; chaperone-mediated protein folding; negative regulation of apoptotic DNA fragmentation; negative regulation of deoxyribonuclease activity; negative regulation of execution phase of apoptosis; positive regulation of apoptotic process; thymocyte apoptotic process
Reference #:  O54786 (UniProtKB)
Alt. Names/Synonyms: A330085O09Rik; DFF-45; DFF35; Dff45; Dffa; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, alpha subunit; ICAD; ICAD-L; ICAD-S; Inhibitor of CAD; OTTMUSP00000011788; OTTMUSP00000011789; RP23-121D17.3
Gene Symbols: Dffa
Molecular weight: 36,572 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling
Select Structure to View Below

DFFA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein