DFFA
Inhibitor of the caspase-activated DNase (DFF40). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Hydrolase |
Chromosomal Location of mouse Ortholog: 4|4 E2 |
Cellular Component:
chromatin; cytoplasm; cytosol; nucleus; plasma membrane; protein-containing complex
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Molecular Function:
deoxyribonuclease inhibitor activity; molecular adaptor activity; protein binding; protein domain specific binding; protein folding chaperone
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Biological Process:
apoptotic DNA fragmentation; apoptotic process; chaperone-mediated protein folding; negative regulation of apoptotic DNA fragmentation; negative regulation of deoxyribonuclease activity; negative regulation of execution phase of apoptosis; positive regulation of apoptotic process; thymocyte apoptotic process
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Reference #:
O54786
(UniProtKB)
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Alt. Names/Synonyms: A330085O09Rik; DFF-45; DFF35; Dff45; Dffa; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, alpha subunit; ICA; ICAD; ICAD-L; ICAD-S; Inhibitor of CAD; OTTMUSP00000011788; OTTMUSP00000011789; RP23-121D17.3
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Gene Symbols: Dffa
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Molecular weight:
36,572 Da
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Basal Isoelectric point:
4.8
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Death Receptor Signaling
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