DFFA Inhibitor of the caspase-activated DNase (DFF40). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Hydrolase
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component:  cytosol; nuclear chromatin; nucleoplasm; nucleus; plasma membrane
Molecular Function:  deoxyribonuclease inhibitor activity; protein binding; protein binding involved in protein folding; protein domain specific binding
Biological Process:  apoptotic DNA fragmentation; chaperone-mediated protein folding; negative regulation of apoptotic DNA fragmentation; negative regulation of deoxyribonuclease activity; negative regulation of execution phase of apoptosis; positive regulation of apoptotic process; thymocyte apoptotic process
Reference #:  O00273 (UniProtKB)
Alt. Names/Synonyms: DFF-45; DFF1; DFF45; DFFA; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; ICAD; Inhibitor of CAD
Gene Symbols: DFFA
Molecular weight: 36,522 Da
Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DFFA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein