CPOX Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. Belongs to the aerobic coproporphyrinogen-III oxidase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 16|16 C1.2
Cellular Component:  cytoplasm; cytosol; membrane; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion
Molecular Function:  coproporphyrinogen oxidase activity; identical protein binding; oxidoreductase activity; protein homodimerization activity; sodium:potassium-exchanging ATPase activity; structural constituent of eye lens
Biological Process:  heme biosynthetic process; oxidation-reduction process; porphyrin-containing compound biosynthetic process; potassium ion transport; protoporphyrinogen IX biosynthetic process; sodium ion transport
Reference #:  P36552 (UniProtKB)
Alt. Names/Synonyms: cac; clone 560; Coprogen oxidase; Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) (COX); coproporphyrinogen oxidase; Coproporphyrinogen-III oxidase, mitochondrial; Coproporphyrinogenase; COX; Cpo; Cpox; CPX; HCP; HEM6; nct; Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Gene Symbols: Cpox
Molecular weight: 49,715 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene