CRMP-2 Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 8p21.2
Cellular Component:  cytosol; membrane; microtubule; plasma membrane
Molecular Function:  dihydropyrimidinase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; identical protein binding; protein binding
Biological Process:  cell differentiation; cytoskeleton organization; endocytosis; nervous system development; nucleobase-containing compound metabolic process; pyrimidine nucleobase catabolic process; signal transduction
Reference #:  Q16555 (UniProtKB)
Alt. Names/Synonyms: Collapsin response mediator protein 2; collapsin response mediator protein hCRMP-2; CRMP-2; CRMP2; DHPRP2; dihydropyrimidinase like 2; dihydropyrimidinase-like 2; dihydropyrimidinase-like 2 long form; Dihydropyrimidinase-related protein 2; DPYL2; DPYSL2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2; Unc-33-like phosphoprotein 2
Gene Symbols: DPYSL2
Molecular weight: 62,294 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CRMP-2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein