CPOX Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. Belongs to the aerobic coproporphyrinogen-III oxidase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 3q11.2
Cellular Component:  cytoplasm; cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion
Molecular Function:  coproporphyrinogen oxidase activity; protein homodimerization activity; structural constituent of eye lens
Biological Process:  heme biosynthetic process; protoporphyrinogen IX biosynthetic process; response to arsenic-containing substance; response to insecticide; response to iron ion; response to lead ion; response to methylmercury
Disease: Coproporphyria, Hereditary; Harderoporphyria
Reference #:  P36551 (UniProtKB)
Alt. Names/Synonyms: Coprogen oxidase; coproporphyrinogen oxidase; Coproporphyrinogen-III oxidase, mitochondrial; Coproporphyrinogenase; COX; CPO; CPOX; CPX; HARPO; HCP; HEM6; homozygous coproporphyria; Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Gene Symbols: CPOX
Molecular weight: 50,152 Da
Basal Isoelectric point: 8.59  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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