CMAS Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Belongs to the CMP-NeuNAc synthase family. Ubiquitously expressed. Expressed in pancreas, kidney, liver, skeletal muscle, lung, placenta, brain, heart, colon, PBL, small intestine, ovary, testis, prostate, thymus and spleen. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC; Transferase
Chromosomal Location of Human Ortholog: 12p12.1
Cellular Component:  nucleoplasm
Biological Process:  N-acetylneuraminate metabolic process
Reference #:  Q8NFW8 (UniProtKB)
Alt. Names/Synonyms: CMAS; CMP-N-acetylneuraminic acid synthase; CMP-N-acetylneuraminic acid synthetase; CMP-Neu5Ac synthetase; CMP-NeuNAc synthase; CMP-NeuNAc synthetase; cytidine 5'-monophosphate N-acetylneuraminic acid synthetase; cytidine monophosphate N-acetylneuraminic acid synthetase; cytidine monophospho-N-acetylneuraminic acid synthetase; N-acylneuraminate cytidylyltransferase; NEUA
Gene Symbols: CMAS
Molecular weight: 48,379 Da
Basal Isoelectric point: 8.16  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene