CBX1 Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Expressed in all adult and embryonic tissues. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of mouse Ortholog: 11 D|11 60.11 cM
Cellular Component:  chromatin; chromocenter; chromosome, centromeric region; chromosome, telomeric region; female pronucleus; male pronucleus; nucleus; pericentric heterochromatin; site of DNA damage; spindle
Molecular Function:  chromatin binding; DNA binding; enzyme binding; histone methyltransferase binding; identical protein binding; methylated histone binding; molecular adaptor activity; protein binding
Biological Process:  cellular response to DNA damage stimulus; chromatin organization; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II
Reference #:  P83917 (UniProtKB)
Alt. Names/Synonyms: Cbx; Cbx-r; Cbx-rs2; Cbx1; chromobox 1; chromobox homolog 1; chromobox homolog 1 (Drosophila HP1 beta); Chromobox protein homolog 1; E430007M08Rik; Heterochromatin protein 1 homolog beta; Heterochromatin protein p25; HP1; HP1 beta; HP1B; Hp1be; Hp1beta; M31; MOD; MOD1; Modifier 1 protein; OTTMUSP00000001556
Gene Symbols: Cbx1
Molecular weight: 21,418 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene