CBX1 Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Expressed in all adult and embryonic tissues. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of human Ortholog: 17q21.32
Cellular Component:  chromatin; chromocenter; chromosome, centromeric region; chromosome, telomeric region; female pronucleus; heterochromatin; male pronucleus; nucleoplasm; nucleus; pericentric heterochromatin; site of DNA damage; spindle
Molecular Function:  chromatin binding; DNA binding; enzyme binding; histone methyltransferase binding; identical protein binding; methylated histone binding; molecular adaptor activity; protein binding
Biological Process:  cellular response to DNA damage stimulus; chromatin organization; negative regulation of transcription by RNA polymerase II
Reference #:  P83916 (UniProtKB)
Alt. Names/Synonyms: CBX; CBX1; chromobox 1; chromobox homolog 1 (HP1 beta homolog Drosophila ); Chromobox protein homolog 1; Heterochromatin protein 1 homolog beta; heterochromatin protein 1-beta; Heterochromatin protein p25; heterochromatin protein p25 beta; HP1 beta; HP1 beta homolog; HP1-BETA; HP1Hs-beta; HP1Hsbeta; M31; MOD1; Modifier 1 protein; p25beta
Gene Symbols: CBX1
Molecular weight: 21,418 Da
Basal Isoelectric point: 4.85  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CBX1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein