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CBX1
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Expressed in all adult and embryonic tissues. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of human Ortholog: 17q21.32 |
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Cellular Component:
chromatin; chromocenter; chromosome, centromeric region; chromosome, telomeric region; female pronucleus; heterochromatin; male pronucleus; nucleoplasm; nucleus; pericentric heterochromatin; site of DNA damage; spindle
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Molecular Function:
chromatin binding; DNA binding; enzyme binding; histone methyltransferase binding; identical protein binding; methylated histone binding; molecular adaptor activity; protein binding
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Biological Process:
cellular response to DNA damage stimulus; chromatin organization; negative regulation of transcription by RNA polymerase II
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Reference #:
P83916
(UniProtKB)
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Alt. Names/Synonyms: CBX; CBX1; chromobox 1; chromobox homolog 1 (HP1 beta homolog Drosophila ); Chromobox protein homolog 1; Heterochromatin protein 1 homolog beta; heterochromatin protein 1-beta; Heterochromatin protein p25; heterochromatin protein p25 beta; HP1 beta; HP1 beta homolog; HP1-BETA; HP1Hs-beta; HP1Hsbeta; M31; MOD1; Modifier 1 protein; p25beta
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Gene Symbols: CBX1
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Molecular weight:
21,418 Da
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Basal Isoelectric point:
4.85
Predict pI for various phosphorylation states
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CST Pathways:
Histone Methylation
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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