CREM iso2 a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. An important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative splice isoforms allow this protein to exert spatial and temporal specificity to cAMP responsiveness. Twentyeight alternatively spliced isoforms of the human protein have been described, with some of them functioning as activators and some as repressors of transcription. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 10p11.21
Cellular Component:  cytoplasm; nucleus
Molecular Function:  cAMP response element binding protein binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  cell differentiation; fatty acid metabolic process; glucose metabolic process; glycosphingolipid metabolic process; multicellular organism development; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; regulation of transcription, DNA-templated; retinoic acid receptor signaling pathway; rhythmic process; signal transduction; spermatogenesis
Reference #:  Q03060-2 (UniProtKB)
Alt. Names/Synonyms: cAMP response element modulator; cAMP responsive element modulator; cAMP-responsive element modulator; CREM; hCREM 2alpha-b protein; hCREM 2beta-a protein; hCREM-2; ICER; Inducible cAMP early repressor; inducible cAMP early repressor ICER; MGC111110; MGC17881; MGC41893
Gene Symbols: CREM
Molecular weight: 26,320 Da
Basal Isoelectric point: 8.26  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
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CREM iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene