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ATP5J
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes. Belongs to the eukaryotic ATPase subunit F6 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Mitochondrial |
| Chromosomal Location of Human Ortholog: 21q21.3 |
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Cellular Component:
cell surface; extracellular space; mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); mitochondrion
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Molecular Function:
protein-containing complex binding; proton transmembrane transporter activity; transmembrane transporter activity
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Biological Process:
ATP biosynthetic process; cristae formation; mitochondrial ATP synthesis coupled proton transport; negative regulation of arachidonic acid secretion; negative regulation of prostaglandin secretion; positive regulation of blood pressure; positive regulation of heart rate; response to muscle activity
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Reference #:
P18859
(UniProtKB)
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Alt. Names/Synonyms: ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6; ATP synthase-coupling factor 6, mitochondrial; ATP5; ATP5A; ATP5J; ATPase subunit F6; ATPM; CF6; coupling factor 6; F6; mitochondrial ATP synthase, coupling factor 6; mitochondrial ATP synthase, subunit F6; mitochondrial ATPase coupling factor 6; proliferation-inducing protein 36
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Gene Symbols: ATP5J
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Molecular weight:
12,588 Da
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Basal Isoelectric point:
9.52
Predict pI for various phosphorylation states
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