SLC25A4 Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. Belongs to the mitochondrial carrier (TC 2.A.29) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 4q35.1
Cellular Component:  integral component of mitochondrial membrane; integral component of plasma membrane; mitochondrial inner membrane; mitochondrion
Molecular Function:  adenine transmembrane transporter activity; protein binding
Biological Process:  adenine transport; ADP transport; apoptotic mitochondrial changes; ATP transport; generation of precursor metabolites and energy; mitochondrial genome maintenance; negative regulation of necroptotic process; regulation of insulin secretion; transmembrane transport; viral process
Disease: Mitochondrial Dna Depletion Syndrome 12 (cardiomyopathic Type); Mitochondrial Dna Depletion Syndrome 12a (cardiomyopathic Type), Autosomal Dominant; Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 2
Reference #:  P12235 (UniProtKB)
Alt. Names/Synonyms: AAC1; Adenine nucleotide translocator 1; adenine nucleotide translocator 1 (skeletal muscle); adenine nucleotide translocator), member 4; ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; ADP/ATP translocase 1; ADT1; ANT; ANT 1; ANT1; heart/skeletal muscle ATP/ADP translocator; PEO2; PEO3; SLC25A4; solute carrier family 25 (mitochondrial carrier; Solute carrier family 25 member 4; T1
Gene Symbols: SLC25A4
Molecular weight: 33,064 Da
Basal Isoelectric point: 9.78  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene