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MLP
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. Belongs to the MARCKS family. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation |
| Chromosomal Location of human Ortholog: 1p35.1 |
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Cellular Component:
cytoplasm; cytoskeleton; plasma membrane
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Molecular Function:
actin filament binding; calmodulin binding; protein binding
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Biological Process:
actin filament organization; cell population proliferation; central nervous system development; positive regulation of cell population proliferation
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Reference #:
P49006
(UniProtKB)
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Alt. Names/Synonyms: F52; Mac-MARCKS; MacMARCKS; Macrophage myristoylated alanine-rich C kinase substrate; MARCKS like 1; MARCKS-like 1; MARCKS-like protein 1; MARCKS-related protein; MARCKSL1; MLP; MLP1; MRP
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Gene Symbols: MARCKSL1
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Molecular weight:
19,529 Da
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Basal Isoelectric point:
4.68
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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