MLP Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. Belongs to the MARCKS family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 1p35.1
Cellular Component:  cytoplasm; cytoskeleton; plasma membrane
Molecular Function:  actin binding; calmodulin binding; protein binding
Biological Process:  positive regulation of cell proliferation
Reference #:  P49006 (UniProtKB)
Alt. Names/Synonyms: F52; Mac-MARCKS; MacMARCKS; Macrophage myristoylated alanine-rich C kinase substrate; MARCKS-like 1; MARCKS-like protein 1; MARCKS-related protein; MARCKSL1; MLP; MLP1; MRP
Gene Symbols: MARCKSL1
Molecular weight: 19,529 Da
Basal Isoelectric point: 4.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MLP

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene