TLR8 Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family. Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component:  endolysosome membrane; endoplasmic reticulum membrane; endosome membrane; external side of plasma membrane; Golgi membrane; integral component of membrane
Molecular Function:  DNA binding; double-stranded RNA binding; drug binding; RNA binding; signaling receptor activity; single-stranded RNA binding; transmembrane signaling receptor activity
Biological Process:  cellular response to mechanical stimulus; defense response to virus; I-kappaB kinase/NF-kappaB signaling; immunoglobulin mediated immune response; innate immune response; microglial cell activation; MyD88-dependent toll-like receptor signaling pathway; negative regulation of interleukin-12 secretion; positive regulation of innate immune response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 secretion; positive regulation of interleukin-8 biosynthetic process; regulation of protein phosphorylation; response to virus; toll-like receptor 8 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Reference #:  Q9NR97 (UniProtKB)
Alt. Names/Synonyms: CD288; MGC119599; MGC119600; TLR8; toll like receptor 8; Toll-like receptor 8
Gene Symbols: TLR8
Molecular weight: 119,828 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene