GluR5 Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily. Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 21q21.3
Cellular Component:  cell junction; integral component of plasma membrane; plasma membrane
Molecular Function:  kainate selective glutamate receptor activity
Biological Process:  central nervous system development; chemical synaptic transmission; glutamate receptor signaling pathway; ion transmembrane transport; ionotropic glutamate receptor signaling pathway; nervous system development; regulation of postsynaptic membrane potential; regulation of synaptic transmission, glutamatergic
Reference #:  P39086 (UniProtKB)
Alt. Names/Synonyms: EAA3; EEA3; Excitatory amino acid receptor 3; GLR5; GluK1; GluR-5; GLUR5; glutamate ionotropic receptor kainate type subunit 1; Glutamate receptor 5; Glutamate receptor ionotropic, kainate 1; Glutamate receptor, ionotropic kainate 1; glutamate receptor, ionotropic, kainate 1; GRIK1
Gene Symbols: GRIK1
Molecular weight: 103,981 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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