GluR5 Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily. Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q11
Cellular Component:  cell junction; dendrite; glutamatergic synapse; integral component of membrane; integral component of presynaptic membrane; ionotropic glutamate receptor complex; kainate selective glutamate receptor complex; membrane; neuronal cell body; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic membrane; receptor complex; synapse; terminal bouton
Molecular Function:  drug binding; extracellularly glutamate-gated ion channel activity; glutamate binding; glutamate receptor activity; ionotropic glutamate receptor activity; kainate selective glutamate receptor activity; protein binding; protein homodimerization activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated cation channel activity
Biological Process:  adult behavior; behavioral response to pain; cation transmembrane transport; chemical synaptic transmission; excitatory postsynaptic potential; inhibitory postsynaptic potential; ion transmembrane transport; ionotropic glutamate receptor signaling pathway; membrane depolarization; modulation of chemical synaptic transmission; negative regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; nervous system development; positive regulation of gamma-aminobutyric acid secretion; positive regulation of synaptic transmission, GABAergic; regulation of membrane potential; regulation of short-term neuronal synaptic plasticity; regulation of synaptic plasticity; synaptic transmission, glutamatergic
Reference #:  P22756 (UniProtKB)
Alt. Names/Synonyms: GluR-5; GluR5; Glutamate receptor 5; Glutamate receptor ionotropic, kainate 1; Glutamate receptor, ionotropic kainate 1; glutamate receptor, ionotropic, kainate 1; Grik1
Gene Symbols: Grik1
Molecular weight: 107,840 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene