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PIK4CB
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking. Inhibited by wortmannin and adenosine. Increased kinase activity upon interaction with NCS1/FREQ. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 1q21.3 |
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Cellular Component:
cytoplasm; cytosol; endosome; Golgi apparatus; Golgi membrane; membrane; mitochondrial outer membrane; perinuclear region of cytoplasm; rough endoplasmic reticulum membrane
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Molecular Function:
1-phosphatidylinositol 4-kinase activity; 14-3-3 protein binding; ATP binding; protein binding
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Biological Process:
inner ear development; lysosome organization; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; receptor-mediated endocytosis; signal transduction
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Disease: Deafness, Autosomal Dominant 87
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Reference #:
Q9UBF8
(UniProtKB)
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Alt. Names/Synonyms: NPIK; Phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta; phosphatidylinositol 4-kinase, wortmannin-sensitive; PI4K-beta; PI4K92; PI4KB; PI4Kbeta; PI4KIII; PI4KIIIBETA; PIK4CB; PtdIns 4-kinase beta; type III phosphatidylinositol 4-kinase beta
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Gene Symbols: PI4KB
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Molecular weight:
91,379 Da
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Basal Isoelectric point:
5.86
Predict pI for various phosphorylation states
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