PIK4CB Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking. Inhibited by wortmannin and adenosine. Increased kinase activity upon interaction with NCS1/FREQ. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 1q21.3
Cellular Component:  cytoplasm; cytosol; endosome; Golgi apparatus; Golgi membrane; membrane; mitochondrial outer membrane; perinuclear region of cytoplasm; rough endoplasmic reticulum membrane
Molecular Function:  1-phosphatidylinositol 4-kinase activity; 14-3-3 protein binding; ATP binding; phosphatidylinositol kinase activity; protein binding
Biological Process:  lysosome organization; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; receptor-mediated endocytosis; signal transduction
Reference #:  Q9UBF8 (UniProtKB)
Alt. Names/Synonyms: NPIK; Phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta; phosphatidylinositol 4-kinase, wortmannin-sensitive; PI4K-beta; PI4K92; PI4KB; PI4Kbeta; PI4KIII; PI4KIIIBETA; PIK4CB; PtdIns 4-kinase beta; type III phosphatidylinositol 4-kinase beta
Gene Symbols: PI4KB
Molecular weight: 91,379 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein