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HLAB iso2
Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Note: This description may include information from UniProtKB.
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| Protein type: Immunoglobulin superfamily; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 17 B1|17 18.63 cM |
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Cellular Component:
cell surface; cis-Golgi network membrane; early endosome; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum exit site; external side of plasma membrane; extracellular space; Golgi apparatus; Golgi medial cisterna; Golgi membrane; lysosomal membrane; MHC class I peptide loading complex; MHC class I protein complex; MHC class Ib protein complex; plasma membrane
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Molecular Function:
14-3-3 protein binding; beta-2-microglobulin binding; CD8 receptor binding; identical protein binding; MHC class I protein binding; natural killer cell lectin-like receptor binding; peptide antigen binding; peptide binding; protein homodimerization activity; protein-containing complex binding; protein-folding chaperone binding; signaling receptor binding; T cell receptor binding; TAP binding; TAP complex binding; TAP1 binding; TAP2 binding
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Biological Process:
adaptive immune response; antibacterial humoral response; antigen processing and presentation; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; antigen processing and presentation of exogenous peptide antigen via MHC class Ib; CD8-positive, alpha-beta T cell activation; defense response to Gram-positive bacterium; immune response; natural killer cell tolerance induction; negative regulation of natural killer cell mediated cytotoxicity; positive regulation of antibody-dependent cellular cytotoxicity; positive regulation of CD8-positive, alpha-beta T cell activation; positive regulation of CD8-positive, alpha-beta T cell proliferation; positive regulation of immunoglobulin production; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of natural killer cell cytokine production; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated immunity; positive regulation of natural killer cell proliferation; positive regulation of T cell mediated cytotoxicity; positive regulation of TRAIL production; positive regulation of tumor necrosis factor production; protection from natural killer cell mediated cytotoxicity; regulation of natural killer cell mediated immunity
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Reference #:
O19441
(UniProtKB)
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Alt. Names/Synonyms: H-2Q1; H2-D1; H2-Q1; Histocompatibility 2, Q region locus 1; HLAB iso2; Major histocompability complex Q1b; MCG68121, isoform CRA_b; MGC91064; MHC class II antigen D; Q1; Q1b; Q1d; Q1k; Qa-1; Qa1; Qed-1
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Gene Symbols: H2-Q1
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Molecular weight:
41,322 Da
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Basal Isoelectric point:
6.52
Predict pI for various phosphorylation states
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