HLAB iso2 Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of mouse Ortholog: 17 B1|17 18.63 cM
Cellular Component:  cell surface; cis-Golgi network membrane; early endosome; early endosome membrane; endoplasmic reticulum; endoplasmic reticulum exit site; external side of plasma membrane; extracellular space; Golgi apparatus; Golgi medial cisterna; Golgi membrane; lysosomal membrane; MHC class I peptide loading complex; MHC class I protein complex; MHC class Ib protein complex; plasma membrane
Molecular Function:  14-3-3 protein binding; beta-2-microglobulin binding; CD8 receptor binding; chaperone binding; identical protein binding; MHC class I protein binding; natural killer cell lectin-like receptor binding; peptide antigen binding; peptide binding; protein homodimerization activity; protein-containing complex binding; signaling receptor binding; T cell receptor binding; TAP complex binding; TAP1 binding; TAP2 binding
Biological Process:  antigen processing and presentation; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; immune response; positive regulation of T cell mediated cytotoxicity
Reference #:  O19441 (UniProtKB)
Alt. Names/Synonyms: H-2Q1; H2-D1; H2-Q1; Histocompatibility 2, Q region locus 1; HLAB iso2; Major histocompability complex Q1b; MCG68121, isoform CRA_b; MGC91064; MHC class II antigen D; Q1; Q1b; Q1d; Q1k; Qa-1; Qa1; Qed-1
Gene Symbols: H2-Q1
Molecular weight: 41,322 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
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HLAB iso2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein