cPLA2 Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase
Chromosomal Location of Human Ortholog: 1q31.1
Cellular Component:  cytoplasmic vesicle; cytosol; endoplasmic reticulum membrane; lipid droplet; mitochondrial inner membrane
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; lysophospholipase activity; phospholipase A2 activity; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine); phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
Biological Process:  arachidonic acid metabolic process; arachidonic acid secretion; cardiolipin acyl-chain remodeling; cellular response to antibiotic; icosanoid biosynthetic process; icosanoid metabolic process; phosphatidic acid biosynthetic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylinositol acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phospholipid metabolic process; platelet activating factor biosynthetic process; regulation of cell proliferation
Disease: Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Reference #:  P47712 (UniProtKB)
Alt. Names/Synonyms: calcium-dependent phospholipid-binding protein; CPLA2; cPLA2-alpha; Cytosolic phospholipase A2; GURDP; Lysophospholipase; MGC126350; PA24A; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2; Phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4; PLA2G4A
Gene Symbols: PLA2G4A
Molecular weight: 85,239 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene