FAM120A May participate in mRNA transport in the cytoplasm. Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses. Belongs to the constitutive coactivator of PPAR-gamma family. Ubiquitously expressed. Highly expressed in scirrhous-type gastric cancer tissues compared with normal gastric mucosa (at protein level). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Tumor suppressor
Chromosomal Location of Human Ortholog: 17p14
Cellular Component:  cytosol; nucleus
Reference #:  NP_001178745 (RefSeq)
Alt. Names/Synonyms: constitutive coactivator of PPAR-gamma-like protein 1; Fam120a; family with sequence similarity 120A; RGD1306643
Gene Symbols: Fam120a
Molecular weight: 122,252 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
Select Structure to View Below

FAM120A

Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene