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NXF1
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Belongs to the NXF family. Expressed ubiquitously. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of rat Ortholog: 1q43 |
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Cellular Component:
cytoplasm; cytoplasmic stress granule; nuclear inclusion body; nuclear pore; nuclear RNA export factor complex; nuclear speck; nucleoplasm; nucleus; transcription export complex
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Molecular Function:
mRNA binding; protein binding; RNA binding
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Biological Process:
mRNA export from nucleus; poly(A)+ mRNA export from nucleus; protein transport; RNA export from nucleus
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Reference #:
O88984
(UniProtKB)
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Alt. Names/Synonyms: Mex67h; mRNA export factor TAP; Nuclear RNA export factor 1; nuclear RNA export factor 1 homolog; Nxf1; Tap; tip associating protein; Tip-associated protein; Tip-associating protein
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Gene Symbols: Nxf1
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Molecular weight:
70,362 Da
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Basal Isoelectric point:
8.94
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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