U2AF2 Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals. Belongs to the splicing factor SR family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 7|7 A1
Cellular Component:  commitment complex; nuclear speck; nucleus; spliceosomal complex; U2-type prespliceosome; U2AF
Molecular Function:  C2H2 zinc finger domain binding; enzyme binding; nucleic acid binding; poly-pyrimidine tract binding; pre-mRNA 3'-splice site binding; protein binding; RNA binding
Biological Process:  mRNA processing; mRNA splicing, via spliceosome; negative regulation of mRNA splicing, via spliceosome; negative regulation of protein ubiquitination; positive regulation of RNA splicing; RNA splicing
Reference #:  P26369 (UniProtKB)
Alt. Names/Synonyms: 65kDa; MGC118033; Splicing factor U2AF 65 kDa subunit; U2 auxiliary factor 65 kDa subunit; U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2; U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa; U2 snRNP auxiliary factor large subunit; U2af2; U2af65
Gene Symbols: U2af2
Molecular weight: 53,517 Da
Basal Isoelectric point: 9.19  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene