NFAT90 RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs. Ubiquitous. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus; RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 8q13
Cellular Component:  cytoplasm; mitochondrion; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function:  AU-rich element binding; DNA binding; DNA-binding transcription factor activity; double-stranded RNA binding; enzyme binding; mRNA 3'-UTR AU-rich region binding; protein binding; single-stranded RNA binding
Biological Process:  defense response to virus; negative regulation of transcription, DNA-templated; negative regulation of translation; negative regulation of viral genome replication; positive regulation of transcription, DNA-templated; protein methylation; protein phosphorylation; regulation of transcription, DNA-templated
Reference #:  Q9JIL3 (UniProtKB)
Alt. Names/Synonyms: Ilf3; interleukin enhancer binding factor 3; Interleukin enhancer-binding factor 3; M phase phosphoprotein 4; NFAT90
Gene Symbols: Ilf3
Molecular weight: 95,935 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
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NFAT90

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene