ZFYVE20 Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; C2H2-type zinc finger protein
Chromosomal Location of mouse Ortholog: 6|6 D1
Cellular Component:  endosome; intracellular membrane-bounded organelle; membrane; plasma membrane
Molecular Function:  metal ion binding; small GTPase binding
Biological Process:  early endosome to Golgi transport; Golgi to lysosome transport; protein transport; regulation of Golgi organization
Reference #:  Q80Y56 (UniProtKB)
Alt. Names/Synonyms: 5330426D11Rik; FYVE finger-containing Rab5 effector protein rabenosyn-5; OTTMUSP00000028129; RAB effector RBSN; Raben; rabenosyn, RAB effector; Rabenosyn-5; RBNS5; Rbsn; Zfyve2; Zfyve20; Zinc finger FYVE domain-containing protein 20; zinc finger, FYVE domain containing 20
Gene Symbols: Rbsn
Molecular weight: 88,491 Da
Basal Isoelectric point: 5.18  Predict pI for various phosphorylation states
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ZFYVE20

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein