AID Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Belongs to the cytidine and deoxycytidylate deaminase family. Strongly expressed in lymph nodes and tonsils. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component:  cytoplasm; nucleus
Molecular Function:  cytidine deaminase activity; identical protein binding; protein binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process:  B cell differentiation; cellular response to lipopolysaccharide; cytidine deamination; defense response to bacterium; DNA demethylation; isotype switching; mRNA processing; negative regulation of methylation-dependent chromatin silencing; regulation of nuclear cell cycle DNA replication; somatic diversification of immunoglobulins; somatic hypermutation of immunoglobulin genes
Disease: Immunodeficiency With Hyper-igm, Type 2
Reference #:  Q9GZX7 (UniProtKB)
Alt. Names/Synonyms: activation induced cytidine deaminase; Activation-induced cytidine deaminase; AICDA; AID; ARP2; CDA2; Cytidine aminohydrolase; epididymis secretory protein Li 284; HEL-S-284; HIGM2; integrated into Burkitt's lymphoma cell line Ramos; Single-stranded DNA cytosine deaminase
Gene Symbols: AICDA
Molecular weight: 23,954 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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