AID
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Belongs to the cytidine and deoxycytidylate deaminase family. Strongly expressed in lymph nodes and tonsils. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.5.4.38; Hydrolase |
Chromosomal Location of mouse Ortholog: 6|6 F1 |
Cellular Component:
cytoplasm; nucleus; P-body; protein-containing complex
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Molecular Function:
catalytic activity; cytidine deaminase activity; deoxycytidine deaminase activity; hydrolase activity; identical protein binding; metal ion binding; protein binding; RNA binding; ubiquitin protein ligase binding; zinc ion binding
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Biological Process:
cellular response to lipopolysaccharide; cytidine deamination; cytidine to uridine editing; defense response to bacterium; defense response to virus; DNA cytosine deamination; DNA demethylation; isotype switching; mRNA processing; negative regulation of DNA methylation-dependent heterochromatin formation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; regulation of nuclear cell cycle DNA replication; somatic diversification of immunoglobulins; somatic hypermutation of immunoglobulin genes
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Reference #:
Q9WVE0
(UniProtKB)
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Alt. Names/Synonyms: activation induced deaminase; Activation-induced cytidine deaminase; Aicda; Aid; Arp2; Cytidine aminohydrolase; Single-stranded DNA cytosine deaminase
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Gene Symbols: Aicda
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Molecular weight:
24,031 Da
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Basal Isoelectric point:
9.42
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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