AID Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.4.38; Hydrolase
Chromosomal Location of Human Ortholog: 6|6 F1
Cellular Component:  cytoplasm; exosome (RNase complex); nucleus; P-body
Molecular Function:  catalytic activity; cytidine deaminase activity; deoxycytidine deaminase activity; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; identical protein binding; metal ion binding; protein binding; RNA binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process:  cytidine deamination; cytidine to uridine editing; defense response to bacterium; defense response to virus; DNA cytosine deamination; isotype switching; mRNA processing; negative regulation of methylation-dependent chromatin silencing; negative regulation of retroviral genome replication; negative regulation of transposition; regulation of DNA stability; somatic diversification of immunoglobulins; somatic hypermutation of immunoglobulin genes
Reference #:  Q9WVE0 (UniProtKB)
Alt. Names/Synonyms: activation induced deaminase; Activation-induced cytidine deaminase; Aicda; Aid; Arp2; Cytidine aminohydrolase; Single-stranded DNA cytosine deaminase
Gene Symbols: Aicda
Molecular weight: 24,031 Da
Basal Isoelectric point: 9.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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AID

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene