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HLAC
Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of human Ortholog: 6p21.33 |
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Cellular Component:
cell surface; early endosome membrane; endoplasmic reticulum; ER to Golgi transport vesicle membrane; external side of plasma membrane; extracellular space; Golgi apparatus; Golgi membrane; lumenal side of endoplasmic reticulum membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane; recycling endosome membrane; secretory granule membrane
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Molecular Function:
peptide antigen binding; protein binding; signaling receptor binding; TAP binding
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Biological Process:
adaptive immune response; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; immune response; innate immune response; positive regulation of T cell mediated cytotoxicity
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Disease: Human Immunodeficiency Virus Type 1, Susceptibility To; Psoriasis 1, Susceptibility To
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Reference #:
P10321
(UniProtKB)
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Alt. Names/Synonyms: D6S204; HLA class I histocompatibility antigen, C alpha chain; HLA-C; HLA-C antigen; HLA-Cw; HLA-JY3; HLAC; HLC-C; Human leukocyte antigen C; human leukocyte antigen-C alpha chain; major histocompatibility antigen HLA-C; major histocompatibility complex, class I, C; MHC; MHC class I antigen heavy chain HLA-C; PSORS1
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Gene Symbols: HLA-C
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Molecular weight:
40,649 Da
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Basal Isoelectric point:
5.71
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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