TXN Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). Belongs to the thioredoxin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 9q31.3
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  peptide disulfide oxidoreductase activity; protein binding; protein disulfide oxidoreductase activity; thioredoxin-disulfide reductase activity
Biological Process:  activation of protein kinase B activity; cell redox homeostasis; cellular oxidant detoxification; glycerol ether metabolic process; negative regulation of hydrogen peroxide-induced cell death; negative regulation of protein export from nucleus; negative regulation of transcription by RNA polymerase II; oxidation-reduction process; positive regulation of DNA binding; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling; response to radiation
Reference #:  P10599 (UniProtKB)
Alt. Names/Synonyms: ADF; ATL-derived factor; DKFZp686B1993; MGC61975; SASP; Surface-associated sulphydryl protein; testicular tissue protein Li 199; THIO; Thioredoxin; thioredoxin delta 3; TRDX; TRX; TRX1; TXN; TXN delta 3
Gene Symbols: TXN
Molecular weight: 11,737 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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