Cortactin a cytoskeletal protein that that is involved in coordinating actin reorganization during cell movement. Localizes at the leading edge of lamellipodia during cell migration. Its amino-terminal acidic domain associates with the Arp2/3 and WASP complex at F-actin branches. The central region of the protein contains six repeats of 37 amino acids that are important in F-actin binding and cross-linking. The carboxy-terminus contains a proline-rich region and an SH3 domain that can interact with numerous scaffolding proteins, such as CortBP1 and Shank3. Cortactin may play a role in the organization of transmembrane receptors at postsynaptic densities (PSD) and tight junctions by linking scaffolding proteins to the actin network. It is degraded in a caspase-dependent manner during apoptosis. It is overexpressed in numerous cancers with poor patient prognosis. It may contribute to tumor cell invasion and metastasis. Two splice variant isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7|7 F5
Cellular Component:  actin filament; cell cortex; cell junction; cell projection; clathrin-coated pit; cortical cytoskeleton; cytoplasm; cytoskeleton; cytosol; focal adhesion; Golgi apparatus; growth cone; intracellular membrane-bound organelle; lamellipodium; membrane; mitotic spindle midzone; plasma membrane; podosome; postsynaptic actin cytoskeleton; ruffle; voltage-gated potassium channel complex
Molecular Function:  Arp2/3 complex binding; profilin binding; proline-rich region binding; protein binding
Biological Process:  actin cytoskeleton reorganization; actin filament polymerization; cell motility; endocytosis; focal adhesion assembly; intracellular protein transport; negative regulation of extrinsic apoptotic signaling pathway; neuron projection morphogenesis; positive regulation of actin filament polymerization; positive regulation of smooth muscle contraction; receptor-mediated endocytosis; regulation of axon extension; substrate-dependent cell migration, cell extension
Reference #:  Q60598 (UniProtKB)
Alt. Names/Synonyms: 1110020L01Rik; cortactin; Cttn; Ems1; mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); OTTMUSP00000017695; Src substrate cortactin; SRC8
Gene Symbols: Cttn
Molecular weight: 61,250 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein