Cortactin Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in the invasiveness of cancer cells, and the formation of metastases. Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Required for stabilization of KCNH1 channels at the cell membrane. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7|7 F5
Cellular Component:  cell cortex; cell junction; cell projection; clathrin-coated pit; cortical cytoskeleton; cytoplasm; cytoskeleton; cytosol; glutamatergic synapse; Golgi apparatus; intracellular membrane-bounded organelle; lamellipodium; membrane; mitotic spindle midzone; plasma membrane; podosome; postsynaptic actin cytoskeleton; ruffle
Molecular Function:  Arp2/3 complex binding; profilin binding; proline-rich region binding; protein binding
Biological Process:  actin cytoskeleton reorganization; actin filament polymerization; cell motility; dendritic spine maintenance; endocytosis; focal adhesion assembly; intracellular protein transport; lamellipodium organization; modification of postsynaptic actin cytoskeleton; negative regulation of extrinsic apoptotic signaling pathway; neuron projection morphogenesis; positive regulation of actin filament polymerization; positive regulation of smooth muscle contraction; receptor-mediated endocytosis; regulation of autophagy of mitochondrion; regulation of axon extension; substrate-dependent cell migration, cell extension
Reference #:  Q60598 (UniProtKB)
Alt. Names/Synonyms: 1110020L01Rik; cortactin; Cttn; Ems1; mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); OTTMUSP00000017695; Src substrate cortactin; SRC8
Gene Symbols: Cttn
Molecular weight: 61,250 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein