Cortactin
Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in the invasiveness of cancer cells, and the formation of metastases. Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Required for stabilization of KCNH1 channels at the cell membrane. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis |
Chromosomal Location of mouse Ortholog: 7|7 F5 |
Cellular Component:
actin filament; anchoring junction; cell cortex; cell junction; cell projection; clathrin-coated pit; cortical actin cytoskeleton; cortical cytoskeleton; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; focal adhesion; glutamatergic synapse; Golgi apparatus; growth cone; intracellular membrane-bounded organelle; lamellipodium; membrane; mitotic spindle midzone; plasma membrane; podosome; postsynapse; postsynaptic actin cytoskeleton; ruffle; site of polarized growth; synapse; voltage-gated potassium channel complex
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Molecular Function:
actin filament binding; Arp2/3 complex binding; profilin binding; proline-rich region binding; protein binding
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Biological Process:
actin cytoskeleton organization; cell motility; dendritic spine maintenance; endocytosis; extrinsic apoptotic signaling pathway; focal adhesion assembly; intracellular protein transport; lamellipodium organization; modification of postsynaptic actin cytoskeleton; modification of postsynaptic structure; negative regulation of extrinsic apoptotic signaling pathway; neuron projection morphogenesis; positive regulation of actin filament polymerization; positive regulation of chemotaxis; positive regulation of smooth muscle contraction; receptor-mediated endocytosis; regulation of actin filament polymerization; regulation of autophagy of mitochondrion; regulation of axon extension; regulation of cell projection assembly; substrate-dependent cell migration, cell extension
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Reference #:
Q60598
(UniProtKB)
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Alt. Names/Synonyms: 1110020L01Rik; cortactin; Cttn; Ems; Ems1; mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); OTTMUSP00000017695; Src substrate cortactin; SRC8
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Gene Symbols: Cttn
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Molecular weight:
61,250 Da
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Basal Isoelectric point:
5.24
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Adherens Junction Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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