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COTL1
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. Belongs to the actin-binding proteins ADF family. Coactosin subfamily. Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding |
| Chromosomal Location of mouse Ortholog: 8|8 E1 |
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Cellular Component:
actin filament; cortical actin cytoskeleton; cytoplasm; cytoskeleton; cytosol; nucleus; site of polarized growth
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Molecular Function:
actin binding; actin filament binding; enzyme binding; protein binding
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Biological Process:
defense response to fungus; regulation of actin filament polymerization
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Reference #:
Q9CQI6
(UniProtKB)
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Alt. Names/Synonyms: 1810074P22Rik; 2010004C08Rik; Clp; coactosin-like 1; coactosin-like 1 (Dictyostelium); Coactosin-like protein; Cotl1
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Gene Symbols: Cotl1
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Molecular weight:
15,944 Da
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Basal Isoelectric point:
5.28
Predict pI for various phosphorylation states
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