COTL1 Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. Belongs to the actin-binding proteins ADF family. Coactosin subfamily. Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. Note: This description may include information from UniProtKB.
Protein type: Actin-binding
Chromosomal Location of Human Ortholog: 8|8 E1
Cellular Component:  cytoplasm; cytoskeleton; nucleus
Molecular Function:  actin binding; enzyme binding; protein binding
Biological Process:  defense response to fungus
Reference #:  Q9CQI6 (UniProtKB)
Alt. Names/Synonyms: 1810074P22Rik; 2010004C08Rik; Clp; coactosin-like 1; coactosin-like 1 (Dictyostelium); Coactosin-like protein; Cotl1
Gene Symbols: Cotl1
Molecular weight: 15,944 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
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COTL1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene