COTL1 Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. Belongs to the actin-binding proteins ADF family. Coactosin subfamily. Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. Note: This description may include information from UniProtKB.
Protein type: Actin-binding
Chromosomal Location of human Ortholog: 16q24.1
Cellular Component:  actin filament; cortical actin cytoskeleton; cytosol; extracellular region; ficolin-1-rich granule lumen; nucleus; secretory granule lumen; site of polarized growth
Molecular Function:  actin binding; actin filament binding; enzyme binding; protein binding
Biological Process:  defense response to fungus; regulation of actin filament polymerization
Reference #:  Q14019 (UniProtKB)
Alt. Names/Synonyms: CLP; coactosin like F-actin binding protein 1; coactosin-like 1; coactosin-like 1 (Dictyostelium); Coactosin-like protein; COTL1; epididymis secretory sperm binding protein; FLJ43657; MGC19733
Gene Symbols: COTL1
Molecular weight: 15,945 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein