MYO5A Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Detected in melanocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of human Ortholog: 15q21.2
Cellular Component:  actomyosin; cytoplasm; cytosol; filopodium tip; glutamatergic synapse; Golgi apparatus; growth cone; insulin-responsive compartment; intermediate filament; melanosome; membrane; microtubule plus-end; neuron projection; neuronal cell body; photoreceptor outer segment; postsynapse; ruffle; smooth endoplasmic reticulum; unconventional myosin complex
Molecular Function:  actin filament binding; ATP binding; calcium ion binding; calmodulin binding; disordered domain specific binding; identical protein binding; microfilament motor activity; protein binding; Rab GTPase binding
Biological Process:  actin filament-based movement; cellular response to insulin stimulus; chemical synaptic transmission; establishment of endoplasmic reticulum localization to postsynapse; exocytosis; hair follicle maturation; insulin secretion; locomotion involved in locomotory behavior; long-chain fatty acid biosynthetic process; melanin biosynthetic process; melanocyte differentiation; melanosome transport; myelination; odontogenesis; post-Golgi vesicle-mediated transport; protein localization to plasma membrane; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; regulation of postsynaptic cytosolic calcium ion concentration; secretory granule localization; synapse organization; vesicle transport along actin filament; vesicle-mediated transport; visual perception
Disease: Griscelli Syndrome, Type 1
Reference #:  Q9Y4I1 (UniProtKB)
Alt. Names/Synonyms: dilute; Dilute myosin heavy chain, non-muscle; GS1; MYH12; MYO5; MYO5A; Myosin heavy chain 12; myosin V; myosin VA; myosin VA (heavy chain 12, myoxin); myosin, heavy polypeptide kinase; Myosin-12; Myosin-Va; Myoxin; MYR12; Unconventional myosin-Va
Gene Symbols: MYO5A
Molecular weight: 215,405 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB