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MYO5A
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Detected in melanocytes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Motor |
| Chromosomal Location of human Ortholog: 15q21.2 |
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Cellular Component:
actin cytoskeleton; actin filament; cytoplasm; cytosol; early endosome; endoplasmic reticulum; filopodium tip; growth cone; insulin-responsive compartment; late endosome; lysosome; melanosome; membrane; myosin complex; neuron projection; peroxisome; recycling endosome; ruffle; vesicle
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Molecular Function:
actin filament binding; ATP binding; calmodulin binding; microfilament motor activity; protein binding; small GTPase binding
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Biological Process:
actin filament organization; actin filament-based movement; cellular response to insulin stimulus; melanosome transport; post-Golgi vesicle-mediated transport; protein localization to plasma membrane; protein transport; regulation of Golgi organization; vesicle transport along actin filament; vesicle-mediated transport
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Disease: Griscelli Syndrome, Type 1
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Reference #:
Q9Y4I1
(UniProtKB)
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Alt. Names/Synonyms: dilute; Dilute myosin heavy chain, non-muscle; GS1; MYH12; MYO5; MYO5A; Myosin heavy chain 12; myosin V; myosin VA; myosin VA (heavy chain 12, myoxin); myosin, heavy polypeptide kinase; Myosin-12; Myosin-Va; Myoxin; MYR12; Unconventional myosin-Va
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Gene Symbols: MYO5A
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Molecular weight:
215,405 Da
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Basal Isoelectric point:
8.7
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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