AML2 Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing. Expressed in gastric cancer tissues (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component:  core-binding factor complex; cytoplasm; cytosol; intracellular membrane-bounded organelle; nuclear chromatin; nucleolus; nucleoplasm; nucleus
Molecular Function:  ATP binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  negative regulation of CD4-positive, alpha-beta T cell differentiation; negative regulation of cell cycle; negative regulation of epithelial cell proliferation; negative regulation of transcription by RNA polymerase II; peripheral nervous system neuron development; positive regulation of CD8-positive, alpha-beta T cell differentiation; positive regulation of transcription, DNA-templated; protein phosphorylation; regulation of transcription, DNA-templated; response to transforming growth factor beta; transcription by RNA polymerase II
Reference #:  Q13761 (UniProtKB)
Alt. Names/Synonyms: Acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; AML2; CBF-alpha-3; CBFA3; Core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 3; FLJ34510; MGC16070; Oncogene AML-2; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2-alpha C; PEBP2A3; PEBP2aC; Polyomavirus enhancer-binding protein 2 alpha C subunit; runt related transcription factor 3; Runt-related transcription factor 3; RUNX family transcription factor 3; RUNX3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2
Gene Symbols: RUNX3
Molecular weight: 44,356 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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