PPAR-alpha Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. Belongs to the nuclear hormone receptor family. NR1 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 7q34
Cellular Component:  nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; drug binding; fatty acid binding; lipid binding; MDM2/MDM4 family protein binding; NFAT protein binding; nuclear receptor activity; nuclear receptor transcription coactivator activity; phosphatase binding; protein binding; protein domain specific binding; protein-containing complex binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II repressing transcription factor binding; sequence-specific DNA binding; signaling receptor activity; steroid hormone receptor activity; transcription coactivator binding; transcription factor binding; transcription regulatory region sequence-specific DNA binding; ubiquitin conjugating enzyme binding; zinc ion binding
Biological Process:  behavioral response to nicotine; cell differentiation; circadian regulation of gene expression; enamel mineralization; epidermis development; fatty acid metabolic process; heart development; hormone-mediated signaling pathway; intracellular receptor signaling pathway; lipoprotein metabolic process; multicellular organism development; negative regulation of appetite; negative regulation of blood pressure; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of cholesterol storage; negative regulation of inflammatory response; negative regulation of leukocyte cell-cell adhesion; negative regulation of macrophage derived foam cell differentiation; negative regulation of neuron death; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of protein binding; negative regulation of receptor biosynthetic process; negative regulation of sequestering of triglyceride; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; regulation of fatty acid metabolic process; regulation of gene expression; regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter; regulation of lipid metabolic process; regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; response to hypoxia; response to insulin; response to lipid; steroid hormone mediated signaling pathway; wound healing
Reference #:  P37230 (UniProtKB)
Alt. Names/Synonyms: Nr1c1; Nuclear receptor subfamily 1 group C member 1; peroxisome proliferator activated receptor alpha; Peroxisome proliferator-activated receptor alpha; Ppar; PPAR-alpha; Ppara
Gene Symbols: Ppara
Molecular weight: 52,377 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
Select Structure to View Below

PPAR-alpha

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA