PPAR-alpha Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. Belongs to the nuclear hormone receptor family. NR1 subfamily. Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of human Ortholog: 22q13.31

Cellular Component: chromatin; nucleoplasm; nucleus

Molecular Function: DNA binding; DNA-binding transcription activator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; lipid binding; MDM2/MDM4 family protein binding; mitogen-activated protein kinase kinase kinase binding; NFAT protein binding; nuclear receptor activity; nuclear steroid receptor activity; phosphatase binding; protein binding; protein domain specific binding; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription coactivator binding; ubiquitin conjugating enzyme binding; zinc ion binding

Biological Process: behavioral response to nicotine; cell differentiation; cellular response to starvation; circadian regulation of gene expression; enamel mineralization; epidermis development; fatty acid metabolic process; gluconeogenesis; heart development; hormone-mediated signaling pathway; intracellular receptor signaling pathway; lipoprotein metabolic process; negative regulation of appetite; negative regulation of blood pressure; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of cholesterol storage; negative regulation of cytokine production involved in inflammatory response; negative regulation of glycolytic process; negative regulation of hepatocyte apoptotic process; negative regulation of inflammatory response; negative regulation of leukocyte cell-cell adhesion; negative regulation of macrophage derived foam cell differentiation; negative regulation of miRNA transcription; negative regulation of neuron death; negative regulation of protein binding; negative regulation of protein kinase B signaling; negative regulation of reactive oxygen species biosynthetic process; negative regulation of sequestering of triglyceride; negative regulation of signaling receptor activity; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of ATP biosynthetic process; positive regulation of DNA-templated transcription; positive regulation of fatty acid beta-oxidation; positive regulation of fatty acid metabolic process; positive regulation of fatty acid oxidation; positive regulation of gluconeogenesis; positive regulation of lipid biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of transformation of host cell by virus; regulation of cellular ketone metabolic process; regulation of circadian rhythm; regulation of fatty acid metabolic process; regulation of fatty acid transport; response to ethanol; response to hypoxia; response to insulin; steroid hormone mediated signaling pathway; wound healing

Reference #: Q07869 (UniProtKB)

Alt. Names/Synonyms: hPPAR; MGC2237; MGC2452; NR1C1; Nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator activated receptor alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; Peroxisome proliferator-activated receptor alpha; PPAR; PPAR-alpha; PPARA; PPARalpha

Gene Symbols: PPARA

Molecular weight: 52,225 Da

Basal Isoelectric point: 5.86 Predict pI for various phosphorylation states

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PPAR-alpha

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