Sialoprotein-2 Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Cellular Component:  extracellular space; vesicle
Molecular Function:  integrin binding
Biological Process:  bone mineralization; cell adhesion; cellular response to growth factor stimulus; extracellular matrix organization; positive regulation of cell adhesion
Reference #:  Q28862 (UniProtKB)
Alt. Names/Synonyms: Bone sialoprotein 2; Bone sialoprotein II; Bone sialoprotein-2 precursor; BSP II; Cell- binding sialoprotein; IBSP; integrin binding sialoprotein; Integrin-binding sialoprotein; SIAL; Sialoprotein-2
Gene Symbols: IBSP
Molecular weight: 34,101 Da
Basal Isoelectric point: 4.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein