Sialoprotein-2 Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component:  extracellular region; extracellular space; vesicle
Molecular Function:  integrin binding
Biological Process:  bone mineralization; cell adhesion; cellular response to growth factor stimulus; extracellular matrix organization; positive regulation of cell adhesion
Reference #:  P21815 (UniProtKB)
Alt. Names/Synonyms: BNSP; Bone sialoprotein 2; Bone sialoprotein II; BSP; BSP II; BSP-II; Cell-binding sialoprotein; IBSP; Integrin-binding sialoprotein; SIAL; SP-II
Gene Symbols: IBSP
Molecular weight: 35,148 Da
Basal Isoelectric point: 4.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Sialoprotein-2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene