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NAC1
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1. Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of Human Ortholog: 19q11 |
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Cellular Component:
cell junction; cytoplasm; intracellular membrane-bounded organelle; nuclear body; nucleoplasm; nucleus
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Molecular Function:
protein binding
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Biological Process:
negative regulation of transcription, DNA-templated; positive regulation of cell proliferation; protein homooligomerization
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Reference #:
O35260
(UniProtKB)
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Alt. Names/Synonyms: BTB (POZ) domain containing 14B; BTB/POZ domain-containing protein 14B; Btbd14b; NAC-1; Nac1; Nacc1; nucleus accumbens associated 1, BEN and BTB (POZ) domain containing; nucleus accumbens-1; Nucleus accumbens-associated protein 1; transcriptional repressor NAC1
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Gene Symbols: Nacc1
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Molecular weight:
56,450 Da
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Basal Isoelectric point:
5.49
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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