Cofilin-1 Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration. Belongs to the actin-binding proteins ADF family. Widely distributed in various tissues. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of human Ortholog: 11q13.1
Cellular Component:  cell-cell junction; cortical actin cytoskeleton; cytoplasm; cytosol; focal adhesion; lamellipodium; lamellipodium membrane; nuclear matrix; nucleus; ruffle membrane
Molecular Function:  actin filament binding; protein binding; signaling receptor binding
Biological Process:  actin cytoskeleton organization; actin filament depolymerization; actin filament fragmentation; cytoskeleton organization; establishment of cell polarity; interleukin-12-mediated signaling pathway; mitotic cytokinesis; negative regulation of apoptotic process; neural crest cell migration; neural fold formation; positive regulation by host of viral process; positive regulation of actin filament depolymerization; protein phosphorylation; regulation of cell morphogenesis; regulation of dendritic spine morphogenesis; response to amino acid; response to virus; Rho protein signal transduction
Reference #:  P23528 (UniProtKB)
Alt. Names/Synonyms: 18 kDa phosphoprotein; CFL; CFL1; COF1; cofilin; cofilin 1; cofilin 1 (non-muscle); Cofilin, non-muscle isoform; Cofilin-1; epididymis secretory protein Li 15; HEL-S-15; p18
Gene Symbols: CFL1
Molecular weight: 18,502 Da
Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA