ILKAP Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. Belongs to the PP2C family. Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of rat Ortholog: 9q36
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  kinase activity; magnesium-dependent protein serine/threonine phosphatase activity; metal ion binding; protein serine/threonine phosphatase activity
Biological Process:  integrin-mediated signaling pathway; phosphorylation; protein dephosphorylation; regulation of nuclear cell cycle DNA replication
Reference #:  Q9Z1Z6 (UniProtKB)
Alt. Names/Synonyms: ILKAP; Integrin-linked kinase-associated serine/threonine phosphatase 2C; PP2Cdelta; protein phosphatase 2C
Gene Symbols: Ilkap
Molecular weight: 42,744 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
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ILKAP

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene