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VASP
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. Belongs to the Ena/VASP family. Highly expressed in platelets. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 1q21 |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; filopodium; focal adhesion; lamellipodium; plasma membrane
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Molecular Function:
actin binding; profilin binding; SH3 domain binding
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Biological Process:
actin cytoskeleton organization; actin polymerization or depolymerization; axon guidance; neural tube closure; positive regulation of actin filament polymerization; protein homotetramerization
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Reference #:
B5DEX4
(UniProtKB)
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Alt. Names/Synonyms: vasodilator-stimulated phosphoprotein; Vasp; Vasp protein
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Gene Symbols: Vasp
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Molecular weight:
39,724 Da
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Basal Isoelectric point:
8.78
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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