VASP Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. Belongs to the Ena/VASP family. Highly expressed in platelets. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q21
Cellular Component:  cell projection; cytoplasm; cytoskeleton; cytosol; filopodium; focal adhesion; lamellipodium; plasma membrane
Molecular Function:  actin binding; profilin binding; SH3 domain binding
Biological Process:  actin cytoskeleton organization; actin polymerization or depolymerization; axon guidance; neural tube closure; positive regulation of actin filament polymerization; protein homotetramerization
Reference #:  B5DEX4 (UniProtKB)
Alt. Names/Synonyms: vasodilator-stimulated phosphoprotein; Vasp; Vasp protein
Gene Symbols: Vasp
Molecular weight: 39,724 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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VASP

Protein Structure Not Found.


Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein