HCN2 Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. Belongs to the potassium channel HCN family. Highly expressed throughout the brain. Detected at low levels in heart. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  HCN channel complex; integral component of plasma membrane; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  cAMP binding; identical protein binding; intracellular cAMP-activated cation channel activity; protein binding; voltage-gated potassium channel activity; voltage-gated sodium channel activity
Biological Process:  cell-cell signaling; cellular response to cAMP; cellular response to cGMP; membrane depolarization during cardiac muscle cell action potential; potassium ion import across plasma membrane; potassium ion transmembrane transport; regulation of ion transmembrane transport; regulation of membrane potential; sodium ion import across plasma membrane; sodium ion transmembrane transport
Reference #:  Q9UL51 (UniProtKB)
Alt. Names/Synonyms: BCNG-2; BCNG2; brain cyclic nucleotide gated channel 2; Brain cyclic nucleotide-gated channel 2; HAC-1; HCN2; hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2; hyperpolarization activated cyclic nucleotide gated potassium channel 2; hyperpolarization activated cyclic nucleotide-gated potassium channel 2; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Gene Symbols: HCN2
Molecular weight: 96,950 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB