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UNC5B
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. Belongs to the unc-5 family. Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of mouse Ortholog: 10 B4|10 31.52 cM |
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Cellular Component:
cytosol; membrane; membrane raft; plasma membrane
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Molecular Function:
netrin receptor activity; protein binding
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Biological Process:
angiogenesis; anterior/posterior axon guidance; apoptotic process; axon guidance; multicellular organism development; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; netrin-activated signaling pathway; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of phosphatidylinositol 3-kinase signaling; signal transduction
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Reference #:
Q8K1S3
(UniProtKB)
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Alt. Names/Synonyms: 6330415E02Rik; A630020F16; D10Bwg0792e; Netrin receptor UNC5B; Protein unc-5 homolog 2; Protein unc-5 homolog B; unc-5 homolog 2; unc-5 homolog B (C. elegans); unc-5 netrin receptor B; unc5 homolog 2; Unc5b; Unc5h; Unc5h2
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Gene Symbols: Unc5b
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Molecular weight:
103,739 Da
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Basal Isoelectric point:
5.77
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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