Myc Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 8q24.21
Cellular Component:  nuclear chromatin; nucleolus; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  activating transcription factor binding; core promoter binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; protein binding; protein dimerization activity; protein-containing complex binding; repressing transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription factor binding
Biological Process:  beta-catenin-TCF complex assembly; branching involved in ureteric bud morphogenesis; cell cycle arrest; cellular iron ion homeostasis; cellular response to DNA damage stimulus; cellular response to drug; cellular response to hypoxia; cellular response to UV; chromatin remodeling; chromosome organization; cytokine-mediated signaling pathway; energy reserve metabolic process; ERK1 and ERK2 cascade; fibroblast apoptotic process; G1/S transition of mitotic cell cycle; MAPK cascade; negative regulation of apoptotic process; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; oxygen transport; positive regulation of cell proliferation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA biosynthetic process; positive regulation of DNA methylation; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of mesenchymal cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; positive regulation of response to DNA damage stimulus; positive regulation of telomerase activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein deubiquitination; protein-DNA complex disassembly; regulation of gene expression; regulation of telomere maintenance; regulation of transcription by RNA polymerase II; response to drug; response to gamma radiation; response to growth factor
Disease: Burkitt Lymphoma
Reference #:  P01106 (UniProtKB)
Alt. Names/Synonyms: avian myelocytomatosis viral oncogene homolog; BHLHE39; c-Myc; Class E basic helix-loop-helix protein 39; MRTL; MYC; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; myc-related translation/localization regulatory factor; MYCC; Proto-oncogene c-Myc; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog (avian)
Gene Symbols: MYC
Molecular weight: 48,804 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Myc

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene